Genetic stability (in vivo) of the attenuated oral rabies virus vaccine SAD B19
Identifieur interne : 000909 ( Istex/Curation ); précédent : 000908; suivant : 000910Genetic stability (in vivo) of the attenuated oral rabies virus vaccine SAD B19
Auteurs : Aline Beckert ; Lutz Geue ; Ad Vos [Allemagne] ; Andreas Neubert [Allemagne] ; Conrad Freuling ; Thomas MüllerSource :
- Microbiology and Immunology [ 0385-5600 ] ; 2009-01.
English descriptors
- KwdEn :
Abstract
The distribution of oral rabies vaccine baits containing replication‐competent live viruses poses certain environmental safety risks; among others, the possibility of reversion to or an increase in virulence. Hence, the genetic stability of the complete genome of the most widely used oral rabies vaccine virus, SAD B19, was examined after four and 10 serial i.c. passages in foxes and mice, respectively. It was shown that the consensus strain of SAD B19 was extremely stable in vivo. After 10 consecutive passages in mice not a single mutation was observed. In foxes, seven single nucleotide exchanges were found between the first and fourth passage, of which only one resulted in an amino acid exchange at position 9240 of the L‐gene. This mutation was not observed during the first three passages and, furthermore, it was shown that this mutation was not linked to enhanced virulence.
Url:
DOI: 10.1111/j.1348-0421.2008.00085.x
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000910
Links to Exploration step
ISTEX:22877F458628FEED277677CE6406C21A3F950EE7Curation
No country items
Aline Beckert<affiliation><mods:affiliation>Institute of Epidemiology, Friedrich‐Loeffler‐Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen</mods:affiliation><wicri:noCountry code="subField">Wusterhausen</wicri:noCountry></affiliation><affiliation><mods:affiliation>Institute of Epidemiology, Friedrich‐Loeffler‐Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen</mods:affiliation><wicri:noCountry code="subField">Wusterhausen</wicri:noCountry></affiliation><affiliation><mods:affiliation>Institute of Epidemiology, Friedrich‐Loeffler‐Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen</mods:affiliation><wicri:noCountry code="subField">Wusterhausen</wicri:noCountry></affiliation><affiliation><mods:affiliation>Institute of Epidemiology, Friedrich‐Loeffler‐Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen</mods:affiliation><wicri:noCountry code="subField">Wusterhausen</wicri:noCountry></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic stability (in vivo) of the attenuated oral rabies virus vaccine SAD B19</title><author><name sortKey="Beckert, Aline" sort="Beckert, Aline" uniqKey="Beckert A" first="Aline" last="Beckert">Aline Beckert</name><affiliation><mods:affiliation>Institute of Epidemiology, Friedrich‐Loeffler‐Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen</mods:affiliation><wicri:noCountry code="subField">Wusterhausen</wicri:noCountry></affiliation></author><author><name sortKey="Geue, Lutz" sort="Geue, Lutz" uniqKey="Geue L" first="Lutz" last="Geue">Lutz Geue</name><affiliation><mods:affiliation>Institute of Epidemiology, Friedrich‐Loeffler‐Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen</mods:affiliation><wicri:noCountry code="subField">Wusterhausen</wicri:noCountry></affiliation></author><author><name sortKey="Vos, Ad" sort="Vos, Ad" uniqKey="Vos A" first="Ad" last="Vos">Ad Vos</name><affiliation wicri:level="1"><mods:affiliation>IDT Biologika GmbH, Am Pharmapark, 06861 Dessau‐Rosslau, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>IDT Biologika GmbH, Am Pharmapark, 06861 Dessau‐Rosslau</wicri:regionArea></affiliation></author><author><name sortKey="Neubert, Andreas" sort="Neubert, Andreas" uniqKey="Neubert A" first="Andreas" last="Neubert">Andreas Neubert</name><affiliation wicri:level="1"><mods:affiliation>IDT Biologika GmbH, Am Pharmapark, 06861 Dessau‐Rosslau, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>IDT Biologika GmbH, Am Pharmapark, 06861 Dessau‐Rosslau</wicri:regionArea></affiliation></author><author><name sortKey="Freuling, Conrad" sort="Freuling, Conrad" uniqKey="Freuling C" first="Conrad" last="Freuling">Conrad Freuling</name><affiliation><mods:affiliation>Institute of Epidemiology, Friedrich‐Loeffler‐Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen</mods:affiliation><wicri:noCountry code="subField">Wusterhausen</wicri:noCountry></affiliation></author><author><name sortKey="Muller, Thomas" sort="Muller, Thomas" uniqKey="Muller T" first="Thomas" last="Müller">Thomas Müller</name><affiliation><mods:affiliation>Institute of Epidemiology, Friedrich‐Loeffler‐Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen</mods:affiliation><wicri:noCountry code="subField">Wusterhausen</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:22877F458628FEED277677CE6406C21A3F950EE7</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1111/j.1348-0421.2008.00085.x</idno><idno type="url">https://api.istex.fr/document/22877F458628FEED277677CE6406C21A3F950EE7/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000910</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000910</idno><idno type="wicri:Area/Istex/Curation">000909</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Genetic stability (in vivo) of the attenuated oral rabies virus vaccine SAD B19</title><author><name sortKey="Beckert, Aline" sort="Beckert, Aline" uniqKey="Beckert A" first="Aline" last="Beckert">Aline Beckert</name><affiliation><mods:affiliation>Institute of Epidemiology, Friedrich‐Loeffler‐Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen</mods:affiliation><wicri:noCountry code="subField">Wusterhausen</wicri:noCountry></affiliation></author><author><name sortKey="Geue, Lutz" sort="Geue, Lutz" uniqKey="Geue L" first="Lutz" last="Geue">Lutz Geue</name><affiliation><mods:affiliation>Institute of Epidemiology, Friedrich‐Loeffler‐Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen</mods:affiliation><wicri:noCountry code="subField">Wusterhausen</wicri:noCountry></affiliation></author><author><name sortKey="Vos, Ad" sort="Vos, Ad" uniqKey="Vos A" first="Ad" last="Vos">Ad Vos</name><affiliation wicri:level="1"><mods:affiliation>IDT Biologika GmbH, Am Pharmapark, 06861 Dessau‐Rosslau, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>IDT Biologika GmbH, Am Pharmapark, 06861 Dessau‐Rosslau</wicri:regionArea></affiliation></author><author><name sortKey="Neubert, Andreas" sort="Neubert, Andreas" uniqKey="Neubert A" first="Andreas" last="Neubert">Andreas Neubert</name><affiliation wicri:level="1"><mods:affiliation>IDT Biologika GmbH, Am Pharmapark, 06861 Dessau‐Rosslau, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>IDT Biologika GmbH, Am Pharmapark, 06861 Dessau‐Rosslau</wicri:regionArea></affiliation></author><author><name sortKey="Freuling, Conrad" sort="Freuling, Conrad" uniqKey="Freuling C" first="Conrad" last="Freuling">Conrad Freuling</name><affiliation><mods:affiliation>Institute of Epidemiology, Friedrich‐Loeffler‐Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen</mods:affiliation><wicri:noCountry code="subField">Wusterhausen</wicri:noCountry></affiliation></author><author><name sortKey="Muller, Thomas" sort="Muller, Thomas" uniqKey="Muller T" first="Thomas" last="Müller">Thomas Müller</name><affiliation><mods:affiliation>Institute of Epidemiology, Friedrich‐Loeffler‐Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen</mods:affiliation><wicri:noCountry code="subField">Wusterhausen</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Microbiology and Immunology</title><idno type="ISSN">0385-5600</idno><idno type="eISSN">1348-0421</idno><imprint><publisher>Blackwell Publishing Asia</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2009-01">2009-01</date><biblScope unit="volume">53</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="16">16</biblScope><biblScope unit="page" to="21">21</biblScope></imprint><idno type="ISSN">0385-5600</idno></series><idno type="istex">22877F458628FEED277677CE6406C21A3F950EE7</idno><idno type="DOI">10.1111/j.1348-0421.2008.00085.x</idno><idno type="ArticleID">MIM085</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0385-5600</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>genetic stability</term><term>oral vaccine</term><term>rabies</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The distribution of oral rabies vaccine baits containing replication‐competent live viruses poses certain environmental safety risks; among others, the possibility of reversion to or an increase in virulence. Hence, the genetic stability of the complete genome of the most widely used oral rabies vaccine virus, SAD B19, was examined after four and 10 serial i.c. passages in foxes and mice, respectively. It was shown that the consensus strain of SAD B19 was extremely stable in vivo. After 10 consecutive passages in mice not a single mutation was observed. In foxes, seven single nucleotide exchanges were found between the first and fourth passage, of which only one resulted in an amino acid exchange at position 9240 of the L‐gene. This mutation was not observed during the first three passages and, furthermore, it was shown that this mutation was not linked to enhanced virulence.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/RenardV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000909 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000909 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= RenardV1
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:22877F458628FEED277677CE6406C21A3F950EE7
|texte= Genetic stability (in vivo) of the attenuated oral rabies virus vaccine SAD B19
}}
| This area was generated with Dilib version V0.6.27. |  |